2-Thiophenesulfonyl chloride Chemical Properties

Melting point:

30-32 °C(lit.)

Boiling point:

130-132 °C14 mm Hg(lit.)

Density 

1.534 (estimate)

refractive index 

1.5722-1.5742

Flash point:

>110°C

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

soluble in Chloroform, Ethyl Acetate

form 

solid

color 

White to Almost white

Water Solubility 

Reacts with water.

Sensitive 

Moisture Sensitive

BRN 

123536

Stability:

Moisture sensitive

CAS DataBase Reference

16629-19-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Thiophene sulfonyl chloride(16629-19-9)

EPA Substance Registry System

2-Thiophenesulfonyl chloride (16629-19-9)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-28A-25-27

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

Hazard Note 

Corrosive

TSCA 

T

HazardClass 

8

PackingGroup 

II

HS Code 

29349990

MSDS

• Language:English Provider:Thiophene-2-sulfonyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Thiophenesulfonyl chloride Usage And Synthesis

Chemical Properties

2-Thiophenesulfonyl chloride is colorless to brown low melting solid or liquid

Uses

2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene

Uses

2-Thiophenesulfonyl chloride is a compound used in the preparation of various pharmaceuticals. Thiophene-2-sulfonyl Chloride was used as an intermediate in the synthesis of β-Cell apoptosis supressor .

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3286, 1974 DOI: 10.1021/jo00936a030

General Description

Kinetics of reactions of 2-thiophenesulfonyl chloride with substituted anilines in methanol has been reported. Kinetics of solvolysis of 2-thiophenesulfonyl chloride in binary solvent mixtures has been studied.

2-Thiophenesulfonyl chloride(16629-19-9)Related Product Information

• Sodium chloride
• Thiophene
• Pivaloyl chloride
• 4-Nitrobenzenesulfonyl chloride
• Ammonium chloride
• Benzenesulfonyl chloride
• Polyvinyl chloride
• Calcium chloride
• Tosyl chloride
• Sulfuryl chloride
• Choline chloride
• Dansyl chloride
• Potassium chloride
• Thionyl chloride
• 2-Thiazolecarboxamidine Hydrochloride
• 2-Thiophenecarboxylic acid
• 2-Thiophenecarboxaldehyde
• 2-Thiopheneacetyl chloride