AP1867
AP1867 Basic information
- Product Name:
- AP1867
- Synonyms:
-
- AP1867
- 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[3-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-
- AP-1867,AP1867
- 2-(3-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid
- dTAG acid
- ({3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]hexahydropyridin-2-yl]carbonyl}oxy)propyl]phenyl}oxy)acetic acid
- (1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
- CAS:
- 195514-23-9
- MF:
- C38H47NO11
- MW:
- 693.78
- Mol File:
- 195514-23-9.mol
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AP1867 Chemical Properties
- Boiling point:
- 814.2±65.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- DMSO : ≥ 125 mg/mL (180.17 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 3.14±0.10(Predicted)
- color
- Light yellow to yellow
- InChIKey
- XCCRAOPQCACRFC-OIFRRMEBSA-N
- SMILES
- N1(C(=O)[C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)CCCC[C@H]1C(O[C@@H](C1=CC=CC(OCC(O)=O)=C1)CCC1=CC=C(OC)C(OC)=C1)=O
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AP1867 Usage And Synthesis
Uses
AP1867 is a synthetic FKBP12F36V-directed ligand[1].
References
[1] Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441. DOI:10.1038/s41589-018-0021-8
[2] Koide K, et al. A synthetic library of cell-permeable molecules. J Am Chem Soc. 2001 Jan 24;123(3):398-408. DOI:10.1021/ja0023377
AP1867Supplier
Shanghai Jiyi Biological Technology Co., LTD Gold
- Tel
- 021-54135696 18516235431
- shgegenetech@163.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070 13913916777;
- info@chemlin.com.cn
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
NanJing Xienuo bio Co.,Ltd.
- Tel
- 025-84112752 13805181430
- 154301870@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com