TRi-1
TRi-1 Basic information
- Product Name:
- TRi-1
- Synonyms:
-
- TRi-1
- TRi-1(TXNRD1 inhibitor 1)
- antitumor,inhibit,TRi 1,Inhibitor,FaDu,thioredoxin reductase 1,glutathione,TRi-1,TRi1,TXNRD1
- Pyridine, 2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitro-
- TRi-1, 10 mM in DMSO
- CAS:
- 246020-68-8
- MF:
- C12H9ClN2O5S
- MW:
- 328.73
- Mol File:
- 246020-68-8.mol
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TRi-1 Chemical Properties
- Boiling point:
- 533.2±50.0 °C(Predicted)
- Density
- 1.502±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 62.5 mg/mL (190.13 mM; Need ultrasonic)
- form
- Solid
- pka
- -8.51±0.29(Predicted)
- color
- Light yellow to yellow
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TRi-1 Usage And Synthesis
Uses
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
in vivo
TRi-1 (10 mg/kg; i.v.; twice a day for 4 days or 5 mg/kg; i.p.; twice a week for 3 weeks) impaires growth and viability of human tumor xenografts and syngeneic mouse tumors[1].
| Animal Model: | SCID mice bearing established human FaDu cell xenografts[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intravenous injection, twice a day for 4 days |
| Result: | Resulted in decreased tumor growth compared to vehicle controls within four days with no signs of overt toxicity or changes in mouse weight relative to vehicle control. |
| Animal Model: | PyMT-MMTV mice that spontaneously develop malignant breast cancer tumors[1] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection, twice a week for 3 weeks |
| Result: | Impaired tumor growth, significantly reduced tumor volumes. |
References
[1] Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. DOI:10.1126/scitranslmed.aaf7444
TRi-1Supplier
Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
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Shanghai JiYi Biotechnology Co. Ltd.
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- 13621943973
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Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
- klq@cw-bio.com