4'-METHYLCHRYSOERIOL Chemical Properties

Melting point:

244 °C (decomp)(Solv: methanol (67-56-1))

Boiling point:

538.3±50.0 °C(Predicted)

Density 

1.402±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 20.83 mg/mL (66.28 mM);Water : < 0.1 mg/mL (insoluble)

pka

6.49±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

InChI

InChI=1S/C17H14O6/c1-21-13-4-3-9(5-15(13)22-2)14-8-12(20)17-11(19)6-10(18)7-16(17)23-14/h3-8,18-19H,1-2H3

InChIKey

AOLOMULCAJQEIG-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(OC)C(OC)=C2)OC2=CC(O)=CC(O)=C2C(=O)C=1

LogP

2.970 (est)

4'-METHYLCHRYSOERIOL Usage And Synthesis

Description

5,7-Dihydroxy-3‘,4’-dimethoxyflavone, also known as 4'-Methylchrysoeriol , is a bioactive Flavonoids found in plants such as Eupatorium odoratum. Studies have shown that 4'-Methylchrysoeriol has death receptor 5 promoter-enhancing activity.

Uses

4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD.

Biological Activity

4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD.

References

[1] Shimada T, et al. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res To DOI:10.1021/tx900127s

4'-METHYLCHRYSOERIOL(4712-12-3)Related Product Information

• CHRYSOERIOL