Basic information Safety Supplier Related

2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Basic information Safety Supplier Related

2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Basic information

Product Name:
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
Synonyms:
  • 2-Fluoro-6-trifluorobenzaldehyde
  • 2-Fluoro-6-(trifluoromethyl)benzaldehyde 97%
  • 2-Fluoro-6-(trifluoromethyl)benzaldehyde97%
  • α,α,α,6-Tetrafluoro-2-tolualdehyde
  • α,α,α,6-Tetrafluoro-o-tolualdehyde
  • 3-Fluoro-2-formylbenzotrifluoride, alpha,alpha,alpha,6-Tetrafluoro-o-tolualdehyde
  • 2-Fluor-6-trifluormethylbenzaldehyd
  • 2-fluoro-6-(trifluoromethyl)benzald
CAS:
60611-24-7
MF:
C8H4F4O
MW:
192.11
EINECS:
625-623-0
Product Categories:
  • Fluorine series
  • Benzaldehyde
  • Aldehydes
  • C8
  • Carbonyl Compounds
Mol File:
60611-24-7.mol
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2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties

Melting point:
155-157°C
Boiling point:
156 °C (lit.)
Density 
1.432 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.458(lit.)
Flash point:
179 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Almost colorless
Sensitive 
Air Sensitive
BRN 
2263481
InChI
InChI=1S/C8H4F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-4H
InChIKey
FAKUGVHRTLCKHB-UHFFFAOYSA-N
SMILES
C(=O)C1=C(C(F)(F)F)C=CC=C1F
CAS DataBase Reference
60611-24-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29130000

MSDS

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2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Usage And Synthesis

Uses

2-Fluoro-6-(trifluoromethyl)benzaldehyde may be employed for the synthesis of diaryl ether, 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)- benzonitrile and substituted benzo[b]thiophene-2-carboxylates.

General Description

2-Fluoro-6-(trifluoromethyl)benzaldehyde participates in the synthesis of 2-amino-5-trifluoromethylquinazoline.

Synthesis

401-80-9

68-12-2

60611-24-7

In a 5L three-necked round-bottomed flask, 3-fluorobenzotrifluoride (492.0 g, 3.0 mol), N,N,N',N'-tetramethylethylenediamine (TMEDA, 383.2 g, 3.3 mol), diisopropylamine (DIPA, 21.3 g, 0.16 mol), and anhydrous tetrahydrofuran (THF, 1.5 L) were added and the reaction system was cooled to -70 to - 78 °C. A solution of n-butyllithium (n-BuLi, 211.5 g, 3.3 mol) was slowly added dropwise at -70 to -78 °C. The reaction was maintained at this temperature for 2 to 3 hours. Subsequently, N,N-dimethylformamide (DMF, 328.7 g, 4.5 mol) was slowly added and the reaction was continued at this temperature for 1-2 hours. After completion of the reaction, it was slowly warmed up to room temperature, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution (500 ml) and extracted with ethyl acetate (500 ml x 3). The organic layers were combined and concentrated to dryness to give 510.1 g of the solid product 2-fluoro-6-trifluoromethylbenzaldehyde in 88.7% yield.

References

[1] Patent: CN107935863, 2018, A. Location in patent: Paragraph 0040-0043; 0053-0054; 0060-0061
[2] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[3] Tetrahedron Letters, 2013, vol. 54, # 45, p. 6053 - 6056

2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDESupplier

Changzhou Anxuan Chemical, Co., Ltd. Gold
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