Basic information Safety Supplier Related

(-)-BICUCULLINE METHBROMIDE

Basic information Safety Supplier Related

(-)-BICUCULLINE METHBROMIDE Basic information

Product Name:
(-)-BICUCULLINE METHBROMIDE
Synonyms:
  • (6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
  • (-)-BICUCULLINE METHBROMIDE
  • [r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide
  • 1(s),9(r)-(-)-bicuculline methobromide
  • (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)
  • 1(S),9(R)-(-)-Bicuculline methbromide
  • d-Bicuculline methobromide
  • (+)-Bicuculline methobromide|||d-Bicuculline methobromide|||(+)-Bicuculline methobromide
CAS:
66016-70-4
MF:
C21H20NO6.Br
MW:
462.294
Mol File:
66016-70-4.mol
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(-)-BICUCULLINE METHBROMIDE Chemical Properties

storage temp. 
2-8°C
solubility 
aqueous base: unstable
form 
solid
color 
white
Water Solubility 
Soluble to 50 mM in water
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Safety Information

Hazard Codes 
T+,N
Risk Statements 
24-28-50
Safety Statements 
24/25-61-45-36/37-28
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
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(-)-BICUCULLINE METHBROMIDE Usage And Synthesis

Uses

1(S),9(R)-(-)-Bicuculline methbromide has been used:

  • as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
  • in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
  • in hypothalamic explant cultures

Biochem/physiol Actions

1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.

storage

Store at RT

(-)-BICUCULLINE METHBROMIDESupplier

Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
TargetMol Chemicals Inc.
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marketing@tsbiochem.com
Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
Aladdin Scientific
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+1-+1(833)-552-7181
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