(-)-BICUCULLINE METHBROMIDE
(-)-BICUCULLINE METHBROMIDE Basic information
- Product Name:
- (-)-BICUCULLINE METHBROMIDE
- Synonyms:
-
- (6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
- (-)-BICUCULLINE METHBROMIDE
- [r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide
- 1(s),9(r)-(-)-bicuculline methobromide
- (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)
- 1(S),9(R)-(-)-Bicuculline methbromide
- d-Bicuculline methobromide
- (+)-Bicuculline methobromide|||d-Bicuculline methobromide|||(+)-Bicuculline methobromide
- CAS:
- 66016-70-4
- MF:
- C21H20NO6.Br
- MW:
- 462.294
- Mol File:
- 66016-70-4.mol
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(-)-BICUCULLINE METHBROMIDE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- aqueous base: unstable
- form
- solid
- color
- white
- Water Solubility
- Soluble to 50 mM in water
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Safety Information
- Hazard Codes
- T+,N
- Risk Statements
- 24-28-50
- Safety Statements
- 24/25-61-45-36/37-28
- RIDADR
- UN 1544 6.1/PG 2
- WGK Germany
- 3
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(-)-BICUCULLINE METHBROMIDE Usage And Synthesis
Uses
1(S),9(R)-(-)-Bicuculline methbromide has been used:
- as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
- in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
- in hypothalamic explant cultures
Biochem/physiol Actions
1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.
storage
Store at RT
(-)-BICUCULLINE METHBROMIDESupplier
Sigma-Aldrich
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