(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Basic information
- Product Name:
- (R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE
- Synonyms:
-
- R(+)-8-HYDROXY-DPAT HYDROBROMIDE FULL 5- HT1A SEROTONIN
- (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
- (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
- Hydroxy-DPAT hydrobromide, (R)-(+)-8-
- (R) (+) 8 Hydroxy DPAT hydrobromide,(R)(+)8HydroxyDPAT hydrobromide
- CAS:
- 78095-19-9
- MF:
- C16H25NO.BrH
- MW:
- 328.291
- Mol File:
- 78095-19-9.mol
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(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Chemical Properties
- storage temp.
- protect from light
- solubility
- H2O: >10mg/mL at ±60°C (with sonication)
- form
- solid
- color
- white to off-white
- optical activity
- [α]25/D +68.2°, c = 1 in methanol(lit.)
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(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Usage And Synthesis
Uses
(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
- in mice to test the activity of the serotonin receptor
- to test its effect on zebrafish melanocyte migration and survival
- to stimulate hippocampal neurons
Biochem/physiol Actions
(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
storage
Desiccate at +4°C
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDESupplier
Sigma-Aldrich
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