(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Basic information
- Product Name:
- (R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE
- Synonyms:
-
- R(+)-8-HYDROXY-DPAT HYDROBROMIDE FULL 5- HT1A SEROTONIN
- (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
- (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
- Hydroxy-DPAT hydrobromide, (R)-(+)-8-
- (R) (+) 8 Hydroxy DPAT hydrobromide,(R)(+)8HydroxyDPAT hydrobromide
- (R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist
- R(+)-8-OH-DPAT hydrobromide
- (R)-(+)-8-Hydroxy-DPAT hydrobromide
- CAS:
- 78095-19-9
- MF:
- C16H25NO.BrH
- MW:
- 328.291
- Mol File:
- 78095-19-9.mol
More
Less
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Chemical Properties
- storage temp.
- protect from light
- solubility
- H2O: >10mg/mL at ±60°C (with sonication)
- form
- solid
- color
- white to off-white
- optical activity
- [α]25/D +68.2°, c = 1 in methanol(lit.)
- Water Solubility
- H2O: >10mg/mL at±60°C (with sonication)
More
Less
More
Less
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE Usage And Synthesis
Uses
(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
- in mice to test the activity of the serotonin receptor
- to test its effect on zebrafish melanocyte migration and survival
- to stimulate hippocampal neurons
Biochem/physiol Actions
(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
in vivo
R(+)-8-OH-DPAT hydrobromide (0.05 mg/kg; s.c.) potentiates SUL (HY-B1059) (10 and 25 mg/kg)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC)[1].
| Animal Model: | 250-350 g, Male Sprague-Dawley albino rats[1] |
| Dosage: | 0.05 mg/kg |
| Administration: | S.c.; 30 min before SUL |
| Result: | Potentiated SUL (HY-B1059) (10 and 25 mg/kg)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC). |
IC 50
5-HT1A Receptor
storage
Desiccate at +4°C
(R)-(+)-8-HYDROXY-DPAT HYDROBROMIDESupplier
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
BOC Sciences
- Tel
- info@bocsci.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com