PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN&
PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN& Basic information
- Product Name:
- PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN&
- Synonyms:
-
- PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN&
- PROPIONYLPROMAZINE HYDROCHLORIDE VETRANA
- PROPIOMAZINE CHLORIDE)
- 1-Propanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-, monohydrochloride
- Propiomazine HCl
- Unii-70bo17yr03
- UGVNGSMLNPWNNA-UHFFFAOYSA-N
- Propiomazine D6 hydrochlorideQ: What is Propiomazine D6 hydrochloride Q: What is the CAS Number of Propiomazine D6 hydrochloride Q: What is the storage condition of Propiomazine D6 hydrochloride Q: What are the applications of Propiomazine D6 hydrochloride
- CAS:
- 1240-15-9
- MF:
- C20H25ClN2OS
- MW:
- 376.94
- Mol File:
- 1240-15-9.mol
PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN& Usage And Synthesis
Uses
Propiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia[1][2].
brand name
Largon (Baxter Healthcare).
in vivo
Propiomazine (0.2 mg/kg, nasal administration, rats) hydrochloride is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) hydrochloride protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) hydrochloride increases plasma prolactin concentrations in rats[5].
References
[1] B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. DOI:10.1159/000195848
[2] Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. PMID:34590703
[3] C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.
[4] F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87(1):46-51. PMID:5782435
[5] Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. DOI:10.3181/00379727-178-42049
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