propiomazine
propiomazine Basic information
- Product Name:
- propiomazine
- Synonyms:
-
- propiomazine
- 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]propan-1-one
- CB-1678
- Wy-1359
- 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
- 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone
- 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
- propiomazine USP/EP/BP
- CAS:
- 362-29-8
- MF:
- C20H24N2OS
- MW:
- 340.48
- EINECS:
- 206-646-1
- Mol File:
- 362-29-8.mol
propiomazine Chemical Properties
- Boiling point:
- bp0.5 235-245°
- Density
- 1.137±0.06 g/cm3(Predicted)
- pka
- pKa 6.6(H2O) (Uncertain)
Safety Information
- Hazardous Substances Data
- 362-29-8(Hazardous Substances Data)
propiomazine Usage And Synthesis
Uses
1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.
Uses
Propiomazine is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.
brand name
Largon (Baxter Healthcare).
in vivo
Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].
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