BOC-D-LEUCINOL 97 Chemical Properties

Boiling point:

213 °C (lit.)

Density 

0.983 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.449(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

pka

12.11±0.46(Predicted)

optical activity

[α]20/D +26°, c = 2 in methanol

Safety Information

WGK Germany 

3

HS Code 

2924190090

BOC-D-LEUCINOL 97 Usage And Synthesis

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

(1) Di-tert-butyl dicarbonate (4.1 g) was slowly added to a solution of 2-amino-4-methylpentan-1-ol (2.0 g) in tetrahydrofuran (THF, 40 mL) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was washed with a solvent mixture of hexane/ethyl acetate (5:1, v/v) to afford the white solid product tert-butyl (1-hydroxy-4-methylpentan-2-yl)carbamate (3.7 g, yield XX%). The product was analyzed by electrospray ionization mass spectrometry (ESI-MS) showing m/z: 240 ([M + Na]+), which is consistent with the expected molecular weight.

References

[1] Patent: US2013/331571, 2013, A1. Location in patent: Paragraph 0179; 0180

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