5-NITROOROTIC ACID, POTASSIUM SALT MONOHYDRATE, 98 Chemical Properties

Melting point:

>300 °C(lit.)

Safety Information

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29335995

5-NITROOROTIC ACID, POTASSIUM SALT MONOHYDRATE, 98 Usage And Synthesis

Application

In Japan, potassium 5-nitroorotate monohydrate is mainly used as an ingredient in over-the-counter multivitamin medications and as an additive in soft drinks. In Western Europe, it is not only a component of pharmaceutical vitamins but also widely used in cosmetics as a nutritional cosmetic matrix, which can be absorbed by skin cells, promoting cell metabolism and inhibiting skin aging. In the United States, there is considerable research on potassium 5-nitroorotate monohydrate. A series of orotic acid-based drugs, such as nitroorotate and aminoorotate, have been developed both domestically and internationally. Potassium 5-nitroorotate monohydrate possesses an asymmetric spatial structure and various coordination functional groups, enabling it to form a rich variety of coordination compounds with different metal ions. Potassium 5-nitroorotate monohydrate is a key intermediate in the synthesis of dipyridamole, which is a precursor in the synthesis of persantin and aggrenox.

Chemical Properties

white to yellow powder

Synthesis

Maintaining cooling to below 50??C, 420 ml (7.68 mol) of concentrated sulfuric acid (H2SO4, about 98%) was added to 169 ml (2.56 mol) of 65% nitric acid (HNO3). Then 200 g of whey acid (1.28 mol; 99.64% purity) was added in batches. The reaction mixture was heated to 50-55??C with stirring and kept for 3 hours. Upon completion of the nitration reaction, the reaction mixture was cooled to ambient temperature (about 10-15??C) and then kept cooled to below 30??C and decanted into 800 ml of water. When the resulting mixture was cooled to about 0-10??C, it was slowly stirred. The precipitated product was filtered and washed with a small amount of cold water and then dried at about 50-60??C to obtain 5-nitro orotate. Weigh KOH, 5-nitro orotate (0.402 g, 2.0 mmol), 1,10-o-phenanthroline (0.360 g, 2.0 mmol) in a round-bottomed flask, add 20 mL of distilled water and 1.0 mL of DMF, and stir for 10 min at room temperature to form a suspension of the mixture, and then transfer it to a stainless steel reactor and react it for 24 h at 100oC, and then naturally cool it to room temperature. Filtered and separated to obtain the bulk crystal 5-nitro orotate potassium salt monohydrate.

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