GW583340 DIHYDROCHLORIDE
GW583340 DIHYDROCHLORIDE Basic information
- Product Name:
- GW583340 DIHYDROCHLORIDE
- Synonyms:
-
- 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P
- 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride
- 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-
- CAS:
- 388082-81-3
- MF:
- C28H25ClFN5O3S2
- MW:
- 598.11
- Mol File:
- 388082-81-3.mol
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GW583340 DIHYDROCHLORIDE Chemical Properties
- Melting point:
- 259.8-262.4 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- DMSO: 9 mg/mL
- form
- solid
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GW583340 DIHYDROCHLORIDE Usage And Synthesis
Definition
ChEBI: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-4-thiazolyl]-4-quinazolinamine is a member of quinazolines.
Biological Activity
Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.