(2-Thiazolyl)methylamine Chemical Properties

Melting point:

180-185°C

Boiling point:

36 °C

Density 

1.204 g/mL at 25 °C

refractive index 

n20/D1.569

Flash point:

104℃

storage temp. 

2-8°C(protect from light)

form 

liquid

pka

7.24±0.40(Predicted)

color 

Yellow-green

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2735PSN1 8 / PGII

HazardClass 

IRRITANT, HYGROSCOPIC, CORROSIVE

HS Code 

2934100090

(2-Thiazolyl)methylamine Usage And Synthesis

Chemical Properties

Off-white to cream color solid

Uses

(2-Thiazolyl)methylamine is a useful compound in the preparation of cephalosporins

Synthesis

The general procedure for the synthesis of 2-thiazole-methyl-amine from the compound (CAS: 171268-82-9) and water (electrophoretic grade) is as follows: 1. Preparation of GG1 thiazol-2-yl-methylamine azide: triphenylphosphine (2.08 g, 7.9 mmol) was added to a solution of 2-azidomethyl-thiazole (1.11 g, 7.9 mmol) in tetrahydrofuran (THF, 20 mL). 2. Reduction reaction: after 1 h, water (214 μL) and ammonium hydroxide sol (0.5 mL) were added sequentially. 3. Post-treatment: The reaction mixture was stirred overnight and subsequently concentrated under vacuum and purified by fast chromatography (eluent: 5% methanol/dichloromethane) to give the title product 2-thiazolemethanamine as a tan oil (645 mg, 72% yield). 4. The product was characterized by 1H NMR (250 MHz, CDCl3) δ 7.7 (d, 1H, J = 2.0 Hz); 7.25 (d, 1H, J = 2.0 Hz); 4.2 (s, 2H); 1.7 (bs, 2H).

References

[1] Patent: US5939398, 1999, A
[2] Patent: US5698526, 1997, A

(2-Thiazolyl)methylamine(55661-33-1)Related Product Information

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