(+)-Biotin-PEG8-CH2CH2NH2
(+)-Biotin-PEG8-CH2CH2NH2 Basic information
- Product Name:
- (+)-Biotin-PEG8-CH2CH2NH2
- Synonyms:
-
- (+)-Biotin-PEG8-CH2CH2NH2
- 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(26-amino-3,6,9,12,15,18,21,24-octaoxahexacos-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
- Biotin-PEG8-CH2CH2NH2/1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(26-amino-3,6,9,12,15,18,21,24-octaoxahexacos-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
- Biotin PEG9-NH2
- (+)-Biotin-PEG8-amine
- N-(26-Amino-3,6,9,12,15,18,21,24-octaoxahexacosyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
- CAS:
- 2183447-27-8
- MF:
- C28H54N4O10S
- MW:
- 638.81
- Mol File:
- 2183447-27-8.mol
More
Less
(+)-Biotin-PEG8-CH2CH2NH2 Chemical Properties
- storage temp.
- 2-8°C, protect from light
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Solid
- color
- White to off-white
More
Less
(+)-Biotin-PEG8-CH2CH2NH2 Usage And Synthesis
Description
Biotin-PEG8-amine is a biotinylation reagent with a terminal primary amine group. The amine group can be coupled to carboxyl groups or 5'phosphate groups to form stable amide bonds. PEG8 arm increases aqueous solubility of the molecules conjugated to the biotin compound and also helps to minimize steric hindrance involved with the binding to avidin molecules.
Uses
Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329
(+)-Biotin-PEG8-CH2CH2NH2 Supplier
Amatek Scientific Co. Ltd.
- Tel
- 0512-56316828
- info@amateksci.com
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Taizhou Nanfeng Pharmaceutical Research Institute
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
Shanghai Haohong Pharmaceutical Co., Ltd.
- Tel
- 400-8210725 4008210725
- malulu@leyan.com