Basic information Safety Supplier Related

(+)-Biotin-PEG8-NHS Ester

Basic information Safety Supplier Related

(+)-Biotin-PEG8-NHS Ester Basic information

Product Name:
(+)-Biotin-PEG8-NHS Ester
Synonyms:
  • (+)-Biotin-PEG8-NHS Ester
  • Biotin-PEG8-SPA
  • 4,7,10,13,16,19,22,25-Octaoxa-28-azatritriacontanoic acid, 33-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2,5-Dioxopyrrolidin-1-yl 29-oxo-33-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontanoate
CAS:
2143968-03-8
MF:
C33H56N4O14S
MW:
764.88
Product Categories:
  • SiChem
  • peg
  • Biotin
Mol File:
2143968-03-8.mol
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(+)-Biotin-PEG8-NHS Ester Chemical Properties

Density 
1.29±0.1 g/cm3(Predicted)
pka
13.90±0.40(Predicted)
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(+)-Biotin-PEG8-NHS Ester Usage And Synthesis

Biological Activity

Biotin-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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