Biotin-PEG7-Amine Chemical Properties

Boiling point:

785.9±60.0 °C(Predicted)

Density 

1.151±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

solid or viscous liquid

pka

13.90±0.40(Predicted)

color 

White to off-white

Biotin-PEG7-Amine Usage And Synthesis

Description

Biotin-PEG7-amine is a biotin PEG reagent that is reactive with NHS ester or with carboxutlic acid in the presence of EDC or HATU activator.

Uses

Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reaction type: Biotinylations
reagent type: cross-linking reagent

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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