PIP5K1A antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Phosphatidylinositol-5-phosphate 4-kinases synthesize phosphatidylinositol-4,5-bisphosphateP2), a key precursor in phosphoinositide signaling that directly modulates the activity of signaling proteins and cellular processes. There are two subfamilies of PIP kinases, type I and II, that generate PtdIns(4,5)P2 from distinct substrate pools. PIP4 type I kinases use PtdIns5P as a substrate, whereas PIP5 type II kinases use PtdIns4P. In mammalian cells, three isoforms of each PIP4K and PIP5K subfamily, encoded by distinct genes, have been characterized. All PIP kinases are stimulated by phosphatidic acid, extensively regulated by ARF and Rho GTPases, and inhibited by protein kinase A and PI-stimulated autophosphorylation.

References

[1] Rameh, L.E. et al. (1997) Nature 390, 192-6.
[2] Zhang, X. et al. (1997) J Biol Chem 272, 17756-61.
[3] Ishihara, H. et al. (1996) J Biol Chem 271, 23611-4.
[4] Loijens, J.C. and Anderson, R.A. (1996) J Biol Chem 271, 32937-43.
[5] Ishihara, H. et al. (1998) J Biol Chem 273, 8741-8.
[6] Itoh, T. et al (1998) J. Biol. Chem. 273, 20292-20299
[7] Boronenkov, I.V. et al. (1998) Mol Biol Cell 9, 3547-60.
[8] Oude Weernink, P.A. et al. (2004) Eur J Pharmacol 500, 87-99.

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