GAPDH (14C10) Rabbit mAb (HRP Conjugate) Usage And Synthesis

Description

This antibody is conjugated to the carbohydrate groups of horseradish peroxidase (HRP) via its amine groups. The unconjugated GAPDH (14C10) Rabbit mAb.

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey;Bovine;Pig

Background

Glyceraldehyde-3-phosphate dehydrogenase catalyzes the phosphorylation of glyceraldehyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue, GAPDH is thought to be a constitutively expressed housekeeping protein. For this reason, GAPDH mRNA and protein levels are often measured as controls in experiments quantifying specific changes in expression of other targets. Recent work has elucidated roles for GAPDH in apoptosis, gene expression, and nuclear transport. GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimer's diseases.

References

[1] Barber, R.D. et al. (2005) Physiol. Genomics 21, 389-95.
[2] Hara, M.R. and Snyder, S.H. (2006) Cell Mol. Neurobiol. 26, 527-38.
[3] Zheng, L. et al. (2003) Cell 114, 255-66.
[4] Bae, B.I. et al. (2006) Proc. Natl. Acad. Sci. USA 103, 3405-9.
[5] Wang, Q. et al. (2005) FASEB J. 19, 869-71.

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