ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > Carboxylic acid esters and derivatives > Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Basic information
- Product Name:
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- Synonyms:
-
- ETHYL 3-(2,5-DIFLUOROPHENYL)-3-OXOPROPANOATE
- ETHYL 2,5-DIFLUOROBENZOYLACETATE
- 3-(2,5-Difluoro-phenyl)-3-oxo-propionic acid ethyl ester
- Ethyl 3-(2,5-difluorophenyl)
- 2-fluoro-3-(3-fluorophenyl)-3-oxopropanoic acid ethyl ester
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate 95+%
- Benzenepropanoic acid, 2,5-difluoro-β-oxo-, ethyl ester
- Ethyl 2,5-difluoro-β-oxobenzenepropanoate
- CAS:
- 887267-53-0
- MF:
- C11H10F2O3
- MW:
- 228.19
- Mol File:
- 887267-53-0.mol
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Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Chemical Properties
- Boiling point:
- 275.7±25.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- pka
- 10.28±0.50(Predicted)
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Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Usage And Synthesis
Uses
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate is commonly utilized in organic synthesis as C-nucleophiles. One specific example is its reaction with the N-terminal electrophile CF3CHN2, resulting in the formation of CF3-heterocycles, namely ethyl 6-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydrocinnoline-3-carboxylate[1].
References
[1] Arkhipov A, et al. Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N?Atom. Organic Letters, 2016; 18: 3406–3409.
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoateSupplier
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