2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties

Melting point:

162 °C

Boiling point:

0°C

Density 

1.332±0.06 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

2-8°C

pka

1.35±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

HazardClass 

IRRITANT

HS Code 

2934100090

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-[1-(tert-butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid from ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate: ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid (2.0 g) was dissolved in ethanol (10 mL) and tetrahydrofuran (10 mL) as a mixed solvents and 2 N aqueous sodium hydroxide solution (5 mL) was added. The reaction mixture was stirred at 60 °C for 2 hours. After completion of the reaction, the pH was adjusted to 1 with 1 N hydrochloric acid and a precipitate was precipitated, which was collected by filtration and dried to give a light-colored solid product (1.7 g, 94% yield).

References

[1] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0599; 0602; 0603

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID(668484-45-5)Related Product Information

• TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• 4-Formyl-2-isopropylthiazole
• 4-Thiazolecarboxylicacid,2-(1-methylethyl)-(9CI)
• tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate
• 2-PROPYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
• 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID
• TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE