2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE
2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE Basic information
- Product Name:
- 2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE
- Synonyms:
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- 2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE
- 5-Pyrimidinecarbonitrile, 2-[[(2-chlorophenyl)methyl]thio]-1,6-dihydro-6-oxo-4-phenyl-
- BET-IN-7
- CAS:
- 303985-05-9
- MF:
- C18H12ClN3OS
- MW:
- 353.83
- Mol File:
- Mol File
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2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE Chemical Properties
- Boiling point:
- 512.9±60.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 4.66±0.50(Predicted)
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2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE Usage And Synthesis
Uses
BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1].
References
[1] Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238: DOI:10.1016/j.ejmech.2022.114423