1-ADAMANTANAMINE SULFATE Chemical Properties

Melting point:

300 °C

storage temp. 

Store below +30°C.

solubility 

Aqueous Acid (Slightly), Aqueous Base (Slightly)

form 

Fine Crystalline Powder

color 

White

PH

4.9 (100g/l, H2O, 20°C) (slurry)

Stability:

Hygroscopic

InChI

InChI=1S/C10H17N.H2O4S/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h7-9H,1-6,11H2;(H2,1,2,3,4)

InChIKey

MYWTWSQFJLXGGQ-JUMAMQMDSA-N

SMILES

NC12CC3CC(CC(C3)C1)C2.S(O)(O)(=O)=O

CAS DataBase Reference

31377-23-8(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

WGK 3 highly water endangering

HS Code 

2921 30 99

MSDS

• Language:English Provider:ACROS

1-ADAMANTANAMINE SULFATE Usage And Synthesis

Chemical Properties

white fine crystalline powder

Uses

Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

Definition

ChEBI: An alkylammonium sulfate salt obtained by combining amantadine and sulfuric acid in a 2:1 ratio. Used as an antiviral and antiparkinson drug.

in vivo

IC 50

CDK2; Bcl-2; Bax

References

[1] Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. DOI:10.1007/s10156-003-0262-6
[2] Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. DOI:10.1212/WNL.0b013e31824e8f0d
[3] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. DOI:10.1016/s0166-3542(02)00199-7
[4] Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. DOI:10.3390/v13040539
[5] Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. DOI:10.1097/ALN.0000000000000352
[6] Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. DOI:10.3892/ijmm.2015.2289

1-ADAMANTANAMINE SULFATE(31377-23-8)Related Product Information

• Amantadine
• N,N-Diethyl-p-phenylenediamine sulfate
• 1-Adamantylacrylate
• 1-ADAMANTANAMINE FUMARATE
• 1,3-Phenylenediamine sulfate
• 2-(2-Hydroxy)ethyl-p-phenylene diamino sulfate
• Adamantanamine sulfate
• 1-AMINO-1-ETHYLCYCLOHEXANE
• 3-METHYLCYCLOHEXYLAMINE
• 1-AMINO-1-PROPYLCYCLOHEXANE
• 1-ADAMANTANAMINE SULFATE
• Diprobutine
• (+/-)-2-AMINOHEPTANE SULFATE
• Cyclooctylamine
• Iso-amyl-ammonium sulfate