2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE Basic information
- Product Name:
- 2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
- Synonyms:
-
- 9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrochloride
- MFCD11052605
- 1H,2H,3H,5H,6H,7H,8H-Cyclopenta[b]quinolin-9-amine
- CBI-BB ZERO/005050
- AURORA KA-7699
- 2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
- 9-AMINO-2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLINE
- AKOS MSC-0106
- CAS:
- 62732-44-9
- MF:
- C12H16N2
- MW:
- 188.27
- EINECS:
- 676-166-9
- Mol File:
- 62732-44-9.mol
2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE Chemical Properties
- Melting point:
- 202-203 °C(Solv: methanol (67-56-1); water (7732-18-5))
- Boiling point:
- 368.0±42.0 °C(Predicted)
- Density
- 1.170±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- form
- A solid
- pka
- 10.88±0.20(Predicted)
- color
- White to off-white
Safety Information
- Hazard Codes
- Xi
- Hazard Note
- Irritant
2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE Usage And Synthesis
Uses
Ipidacrine is used in biological studies as a possible treatment of toxic cognitive disorders.
Definition
ChEBI: 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine is an aminoquinoline.
in vivo
Ipidacrine (1 mg/kg, p.o., repeated and a single dose for 5 days) by repeated administration has more potent antiamnesic effects than by single administration in induced by nucleus basalis of meynert (NBM) induced rats[1].
Ipidacrine (10 mg/kg p.o., a single dose) significantly decreases spontaneous movements, which is more selective as an antiamnesic than either Tacrine (HY-111338) and E-2020 (HY-B0034) in rats[1].
Ipidacrine (6.7 mg/kg, intragastrically, daily for 14 days) leads to statistically more efficient evolving of intracavernous pressure (ICPmax)/maxipressure (MAP) compared with control group in Streptozotocin (STZ) (HY-13753)-induced diabetic rats[3].
| Animal Model: | Rats[1] |
| Dosage: | 1 mg/kg |
| Administration: | p.o., repeated and a single dose for 5 days |
| Result: | The repeated administration of ipidacrine improved amnesia induced by nucleus basalis of meynert (NBM) lesions in the passive avoidance task in rats. |
| Animal Model: | Rats[1] |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | p.o., a single dose |
| Result: | Decreased pupil size and increased salivation at 3 mg/kg, decreased spontaneous movements at 10 mg/kg and decreased body temperature and induced tremor at 30 mg/kg in rats. |
| Animal Model: | Rats with streptozotocin (STZ) (HY-13753) induced diabetes mellitus-induced erectile dysfunction (DMED)[1] |
| Dosage: | 6.7 mg/kg |
| Administration: | crushed, suspended in 1% starch solution and administered intragastrically daily for 14 days |
| Result: | Ipidacrine was as effective as sildenafil and could significantly improve DMED symptoms. |
2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINESupplier
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2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE(62732-44-9)Related Product Information
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- 4-AMINO-2-METHYL-5,6,7,8-TETRAHYDROQUINOLINE
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- 2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
- 2,5-diethylpyridine