(S)-BEL Chemical Properties

Boiling point:

467.0±45.0 °C(Predicted)

Density 

1.538±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C, protect from light

solubility 

DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml

form 

Liquid

color 

Colorless to light yellow

(S)-BEL Usage And Synthesis

Uses

(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 μM[1].

Definition

ChEBI: (S)-Bromoenol lactone is a member of naphthalenes.

IC 50

PLA2

References

[1] Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discriminati DOI:10.1074/jbc.M202568200

(S)-BEL(478288-94-7)Related Product Information

• BROMOENOL LACTONE