2-Methyl-4-phenyl-1H-imidazole Chemical Properties

Melting point:

159-160.5 °C

Boiling point:

396.2±11.0 °C(Predicted)

Density 

1.109±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.13±0.10(Predicted)

Appearance

White to light yellow Solid

Safety Information

Risk Statements 

36

Safety Statements 

26

HazardClass 

IRRITANT

HS Code 

2933299090

2-Methyl-4-phenyl-1H-imidazole Usage And Synthesis

Synthesis

Using stilbene (150 mL) as solvent, benzoylacetamide (10.15 mmol), ammonium acetate (64.86 mmol) and acetic acid (166.6 mmol) were added and the mixture was heated to reflux and azeotropized to remove the water, and the reaction lasted for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and washed with 25 mL of water followed by distillation to remove the solvent to give the crude product. The crude product was purified by column chromatography using silica gel (60-120 mesh) as stationary phase and a solvent mixture of dichloromethane and methanol (100:5, v/v) as mobile phase to give the final target compound 2-methyl-4-phenyl-1H-imidazole.

References

[1] Patent: WO2009/137081, 2009, A2. Location in patent: Page/Page column 49-51

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