URSODEOXYCHOLIC-2,2,4,4-D4 ACID
URSODEOXYCHOLIC-2,2,4,4-D4 ACID Basic information
- Product Name:
- URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- Synonyms:
-
- URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- Ursodeoxycholic-d4 Acid
- (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
- (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
- Ursodiol-d4 (Ursodeoxycholic Acid-d4)
- URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
- Ursodeoxycholic acid-[d4] (Solution)
- URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY
- CAS:
- 347841-46-7
- MF:
- C24H40O4
- MW:
- 392.58
- Product Categories:
-
- Bile Acids - 13C & 2H
- Mol File:
- 347841-46-7.mol
URSODEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
URSODEOXYCHOLIC-2,2,4,4-D4 ACID Usage And Synthesis
Description
Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
Uses
Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.
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URSODEOXYCHOLIC-2,2,4,4-D4 ACID(347841-46-7)Related Product Information
- URSODEOXYCHOLIC ACID ACYL-B-D-GLUCURONIDE
- Glycoursodeoxycholic Acid
- URSODEOXYCHOLIC ACID-24-13C
- Ursodeoxycholic acid
- Ursodeoxycholic Acid-d5
- Ursodeoxycholic Acid Methyl Ester-d5
- Taurolithocholic-d4 Acid
- (3α,5β,7β)- 3,7,22-Trihydroxycholan-24-oic Acid
- α-Muricholic Acid
- (3b,5b,7a,12a)-3,7,12-trihydroxy-Cholan-24-oic acid
- (4R)-4-[(3S,5S,7S,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
- (4R)-4-[(3S,5R,8S,9S,10S,12S,13R,14S)-1,3,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
- Ursodeocycholic Acid-[d4]-3-Sulfate Sodium Salt
- Ursodeocycholic Acid-3-Sulfate Sodium Salt
- (3a,5b,7a,12b)-3,7,12-trihydroxy-Cholan-24-oic acid
- 3,7-DIKETO-5BETA-CHOLAN-24-OIC ACID
- LITHOCHOLIC ACID
- 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid