URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Product Name: URSODEOXYCHOLIC-2,2,4,4-D4 ACID
CAS No.: 347841-46-7
Chemical Name: URSODEOXYCHOLIC-2,2,4,4-D4 ACID
Synonyms: Ursodeoxycholic-d4 Acid;D4-Ursodeoxycholic Acid;2H4]-Ursodeoxycholic Acid;URSODEOXYCHOLIC-2,2,4,4-D4 ACID;Ursodeoxycholic acid-2,2,4,4-d4;Urosodeoxycholic Acid Impurity 28;Ursodeoxycholic acid-[d4] (Solution);Ursodiol-d4 (Ursodeoxycholic Acid-d4);Ursodeoxycholic Acid-2,2,4,4-d4 (Major);Ursodeoxycholic Acid-d4 MaxSpec? Standard
CBNumber: CB3755802
Molecular Formula: C24H40O4
Formula Weight: 392.58
MOL File: 347841-46-7.mol

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URSODEOXYCHOLIC-2,2,4,4-D4 ACID Property

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS Number Unlabeled: 128-13-2
CAS Number Unlabeled: 128-13-2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21892
Product name: Ursodeoxycholic Acid-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 500μg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 21892
Product name: Ursodeoxycholic Acid-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 1mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 21892
Product name: Ursodeoxycholic Acid-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 5mg
Price: $575
Updated: 2024/03/01

IsoSciences

Product number: S13102-0.1
Product name: Ursodeoxycholicacid-[d4](Solution)
Purity: ≥98%
Packaging: 100ug/mL
Price: $103
Updated: 2021/12/16

IsoSciences

Product number: 13102
Product name: UrsodeoxycholicAcid-[d4]
Purity: ≥95%
Packaging: 50mg
Price: $288
Updated: 2021/12/16

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URSODEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties,Usage,Production

Description

Ursodeoxycholic acid-d₄ (UDCA-d₄) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC₅₀ value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.

Uses

Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.

References

[1] PAUL A DAWSON Saul J K. Intestinal transport and metabolism of bile acids.[J]. Journal of Lipid Research, 2015, 56 6: 1085-1099. DOI: 10.1194/jlr.r054114
[2] ANAND K DEO S M B. 3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid.[J]. Drug Metabolism and Disposition, 2009, 37 9: 1938-1947. DOI: 10.1124/dmd.109.027763
[3] R B KIM. Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 291 3: 1204-1209.
[4] C M RODRIGUES. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.[J]. Journal of Clinical Investigation, 1998, 101 12: 2790-2799. DOI: 10.1172/jci1325

URSODEOXYCHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials

Raw materials

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URSODEOXYCHOLIC-2,2,4,4-D4 ACID Suppliers

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347841-46-7, URSODEOXYCHOLIC-2,2,4,4-D4 ACIDRelated Search:

URSODEOXYCHOLIC ACID ACYL-B-D-GLUCURONIDE Glycoursodeoxycholic Acid URSODEOXYCHOLIC ACID-24-13C Ursodeoxycholic acid Ursodeoxycholic Acid-d5 Ursodeoxycholic Acid Methyl Ester-d5 Taurolithocholic-d4 Acid (3α,5β,7β)- 3,7,22-Trihydroxycholan-24-oic Acid α-Muricholic Acid (3b,5b,7a,12a)-3,7,12-trihydroxy-Cholan-24-oic acid (4R)-4-[(3S,5S,7S,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3S,5R,8S,9S,10S,12S,13R,14S)-1,3,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Ursodeocycholic Acid-[d4]-3-Sulfate Sodium Salt Ursodeocycholic Acid-3-Sulfate Sodium Salt (3a,5b,7a,12b)-3,7,12-trihydroxy-Cholan-24-oic acid 3,7-DIKETO-5BETA-CHOLAN-24-OIC ACID LITHOCHOLIC ACID 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid

URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Ursodeoxycholic-d4 Acid

(4R)-4-[(3R,5R,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

(4R)-4-[(3R,5R,7S,8R,9S,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Ursodiol-d4 (Ursodeoxycholic Acid-d4)

URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL

Ursodeoxycholic acid-[d4] (Solution)

URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY

Ursodeoxycholic Acid-d4 MaxSpec? Standard

Ursodeoxycholic Acid-2,2,4,4-d4 (Major)

(4R)-4-[(3R,5S,7S,8R,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

2H4]-Ursodeoxycholic Acid

Urosodeoxycholic Acid Impurity 28

URSODEOXYCHOLICACID(2,2,4,4-D4) IN METHANOL

*Dronedarone Impurity 37 ( Tributylamine)

Ursodeoxycholic acid-2,2,4,4-d4

Ursodeoxycholic Acid-d4: (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d4 acid

D4-Ursodeoxycholic Acid

Ursodeoxycholic acid (2,2,4,4-D?, 98%) CP 95%

Ursodeoxycholic acid (2,2,4,4-D?, 98%) 100 μg/mL in methanol

347841-46-7

C24H36D4O4

Bile Acids - 13C & 2H