α-Muricholic Acid
- Product Name
- α-Muricholic Acid
- CAS No.
- 2393-58-0
- Chemical Name
- α-Muricholic Acid
- Synonyms
- alpha-Muricholate;a-Muricholic acid;α-Muricholic Acid;alfa-Muricholic Acid;D5-α-Muricholic Acid;2H5]-α-Muricholic Acid;DKPMWHFRUGMUKF-GDYCBZMLSA-N;Hyodeoxycholic acid Impurity 13;Ursodeoxycholic Acid Impurity 29;5β-CHOLANIC ACID-3α, 6β, 7α-TRIOL
- CBNumber
- CB11235695
- Molecular Formula
- C24H40O5
- Formula Weight
- 408.58
- MOL File
- 2393-58-0.mol
α-Muricholic Acid Property
- Melting point:
- 200-202 °C
- Boiling point:
- 565.7±40.0 °C(Predicted)
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 20291
- Product name
- α-Muricholic Acid
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 20291
- Product name
- α-Muricholic Acid
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 20291
- Product name
- α-Muricholic Acid
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2024/03/01
- Product number
- M732750
- Product name
- α-MuricholicAcid
- Packaging
- 10mg
- Price
- $1620
- Updated
- 2021/12/16
- Product number
- 18011
- Product name
- α-MuricholicAcid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
α-Muricholic Acid Chemical Properties,Usage,Production
Description
α-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.
Uses
α-Muricholic Acid is an bile acid found in urine. Studies have linked α-Muricholic in the understanding of the complex signaling pathways of hepatic lipid abnormalities with type 2 diabetes and a treatment target for this condition.
Definition
ChEBI: Alpha-muricholic acid is a member of the class of muricholic acids in which the hydroxy groups at positions 6 and 7 have beta- and alpha- configuration respectively. It is a member of muricholic acids, a 6beta-hydroxy steroid and a 7alpha-hydroxy steroid. It is a conjugate acid of an alpha-muricholate.
in vivo
Sulfated and non-sulfated bile acids are determined in the intestines and in the feces of 7-month-old germ-free and conventional male mice. The major bile acids from germ-free mice are cholic acid, α-Muricholic acid and β-Muricholic acid[1].
In the context of primary bile acid, α-Muricholic acid is greatly reduced in high-fat diet (HFD)-soybean protein isolate (SPI) mice compared to the HFD controls[2].
References
[1] HENDRIK J. EYSSEN Jan A M Guido G PARMENTIER. Sulfated Bile Acids in Germ-Free and Conventional Mice[J]. The FEBS journal, 1976, 66 3: 507-514. DOI: 10.1111/j.1432-1033.1976.tb10576.x
[2] TETSUYA UEHARA. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.[J]. Transplantation, 2004, 78 3: 324-332. DOI: 10.1097/01.tp.0000128859.42696.28
[3] KEITA WATANABE. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.[J]. ACS Applied Bio Materials, 2018: e0202083. DOI: 10.1371/journal.pone.0202083
[4] MICHAEL R. LA FRANO . Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice[J]. Nutrition Research, 2017, 46: Pages 11-21. DOI: 10.1016/j.nutres.2017.07.006
α-Muricholic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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