ChemicalBook > CAS DataBase List > 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid

Product Name
3alpha-Hydroxy-7-oxo-5beta-cholanic Acid
CAS No.
4651-67-6
Chemical Name
3alpha-Hydroxy-7-oxo-5beta-cholanic Acid
Synonyms
7-KETOLITHOCHOLIC ACID;Nutriacholic acid;7-Oxolithocholic acid;3α-Hydroxy-7-oxo-5β-cholan-24-oic acid;3α-Hydroxy-7-ketocholanic acid;Chenodeoxycholic acid EP Impurity F;3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID;(R)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-diMethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;OCA-A;7-KLA
CBNumber
CB2430908
Molecular Formula
C24H38O4
Formula Weight
390.56
MOL File
4651-67-6.mol
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3alpha-Hydroxy-7-oxo-5beta-cholanic Acid Property

Melting point:
205°C
Boiling point:
545.9±25.0 °C(Predicted)
Density 
1.124±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
4.76±0.10(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
2.062mg/L at 25℃
InChIKey
DXOCDBGWDZAYRQ-QHVQYUNXNA-N
SMILES
C(O)(=O)CC[C@H]([C@@H]1[C@@]2(C)CC[C@]3([H])[C@@]4(C)CC[C@@H](O)C[C@@]4([H])CC(=O)[C@@]3([H])[C@]2([H])CC1)C |&1:5,6,7,11,13,17,20,25,27,r|
LogP
3.48 at 20℃
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29546
Product name
7-keto Lithocholic Acid
Packaging
1g
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
29546
Product name
7-keto Lithocholic Acid
Packaging
10g
Price
$680
Updated
2024/03/01
Cayman Chemical
Product number
29546
Product name
7-keto Lithocholic Acid
Packaging
500mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29546
Product name
7-keto Lithocholic Acid
Packaging
5g
Price
$384
Updated
2024/03/01
Medical Isotopes, Inc.
Product number
71777
Product name
NutriacholicAcid
Packaging
1g
Price
$650
Updated
2021/12/16
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3alpha-Hydroxy-7-oxo-5beta-cholanic Acid Chemical Properties,Usage,Production

Uses

Nutriacholic Acid (Ursodeoxycholic Acid EP Impurity F) is derivative of Lithocholic Acid (L469180), a cholic acid derivative as TGR5 modulator.

Uses

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid is an intermediate in organic synthesis and pharmaceutical research and development. It can be used to synthesize the choleretic drug Obeticholic acid. Obeticholic acid can inhibit cholic acid synthesis. It is commonly used to treat primary biliary cirrhosis and nonalcoholic fatty liver disease.

Definition

ChEBI: 7-oxolithocholic acid is a bile acid that is lithocholic acid carrying an additional oxo substituent at position 7. It has a role as a human metabolite. It is a bile acid, a monohydroxy-5beta-cholanic acid, an oxo-5beta-cholanic acid and a 3alpha-hydroxy steroid. It is functionally related to a lithocholic acid. It is a conjugate acid of a 7-oxolithocholate.

Flammability and Explosibility

Non flammable

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3alpha-Hydroxy-7-oxo-5beta-cholanic Acid Suppliers

Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
568
Advantage
55
Shandong RuiYue Biotechnology Co., Ltd.
Tel
0531-88581623 18805314509
Fax
0531-88581623
Email
1456922171@126.com
Country
China
ProdList
65
Advantage
50
Yield Pharmaceutical Techonlogy (Suzhou) Co.,Ltd.
Tel
13382188332
Email
307446954@qq.com
Country
China
ProdList
32
Advantage
58
Xuzhou Maikai Biotechnology Co., Ltd.
Tel
13921770081
Email
SVP01@magicbiotech.cn
Country
China
ProdList
510
Advantage
58
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd
Tel
19066311943
Email
815989315@qq.com
Country
China
ProdList
661
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
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View Lastest Price from 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid manufacturers

SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
Product
7-Ketolithocholic acid 4651-67-6
Price
US $0.00-0.00/kgs
Min. Order
20kgs
Purity
95% above
Supply Ability
300tons
Release date
2024-12-11
Wuhan Han Sheng New Material Technology Co.,Ltd
Product
3alpha-Hydroxy-7-oxo-5beta-cholanic Acid 4651-67-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50tons
Release date
2023-08-25
XuZhou Magic Biotechnology Co., Ltd.
Product
3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANICACID 4651-67-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
96%
Supply Ability
20tons
Release date
2022-12-07

4651-67-6, 3alpha-Hydroxy-7-oxo-5beta-cholanic AcidRelated Search:


  • 7-KETOLITHOCHOLIC ACID
  • 3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID
  • 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
  • 5-BETA-CHOLANIC ACID-3-ALPHA-OL-7-ONE
  • 3alpha-Hydroxy-7-oxo-5?cholanic acid
  • 3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid
  • Hydroxycholanicacid
  • 4-(3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetrade cahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid
  • ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
  • alpha-Hydroxy-7-oxo-5beta-cholic acid
  • 7-Ketolithocholic acid (3alpha-hydroxy-7-oxo-5beta-Cholanic acid)
  • Nutriacholic acid
  • 3-ALPHA-HYDROXY-7-OXO-5-BETA-CHOLANOICACID
  • 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID 97+%
  • Cholan-24-oic acid, 3-hydroxy-7-oxo-, (3.alpha.,5.beta.)-
  • Nsc226118
  • 3-Hydoxy-7-ketocholanic acid
  • 3α-Hydroxy-7-oxo-5β-cholan-24-oic acid
  • 3α-Hydroxy-7-oxo-5β-cholanic acid
  • 7-Ketochenodeoxycholic acid
  • 7-Oxo-3α-hydroxy-5β-cholan-24-oic acid
  • 7-Oxolithocholic acid
  • 3-Hydroxy-7-oxocholan-24-oic acid
  • 3a-Hydroxy-7-oxo-5b-cholanic acid
  • (R)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-diMethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • 3alpha-Hydroxy-7-oxo-5beta-cholic acid
  • (3α,5β)-3-Hydroxy-7-oxo-Cholan-24-oic acid
  • Cholan-24-oic acid,6-ethyl-3,7-dihydroxy-,(3α,5β,6β,7β)-
  • 3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic
  • obeticholic acid intermediate 1
  • 3α-Hydroxy-7-keto-5β-cholanic Acid
  • 3α-Hydroxy-7-ketocholanic acid
  • 3Α--hydroxy-7-oxo -5Β- bile acid
  • OCA-A
  • 3ɑ-Hydroxy-7-Oxo-5β-Cholanic Acid
  • ursodeoxycholic acid oxide
  • Ursodeoxycholic Acid EP Impurity F(7-Ketolithocholic Acid)
  • Ursodeoxycholic Acid Impurity 6(Ursodeoxycholic Acid EP Impurity F)
  • 3α-hydroxy-7-oxo-5β-cholanoic acid
  • 3ALFA-HYDROXI-7KETO-5BETA-CHOLAN-24-ACID
  • 3α-Hydroxy-7-oxo-5β-cholic acid
  • 3α-Hydroxy-7-oxo-5b-cholanic acid, 98%
  • Chenodeoxycholic Acid Impurity 6
  • Ursodeoxycholic Acid EP Impurity F
  • 3α-Hydroxy-7-oxo-5β-cholanicAcid&gt
  • 5β-CHOLANIC acid-3α-OL-7-ONE
  • Cholan-24-oic acid, 3-hydroxy-7-oxo-, (3α,5β)-
  • Emtricitabine Impurity 33
  • 7-oxolithocholicaci
  • 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID USP/EP/BP
  • Chenodeoxycholic Acid Impurity 6(Chenodeoxycholic Acid EP Impurity F)
  • Chenodeoxycholic acid EP Impurity F
  • 3α-Hydroxy-7-keto-5β-cholanic Acid
  • Ursodeoxycholic Acid EP Impurity F (Chenodeoxycholic Acid EP Impurity F/ 7-Oxo Ursodeoxycholic Acid/ 7-Oxo Chenodeoxycholic Acid)
  • Chenodeoxycholic Acid EP Impurity F (Ursodeoxycholic Acid EP Impurity F/ 7-Oxo Ursodeoxycholic Acid/ 7-Oxo Chenodeoxycholic Acid)
  • Ursodiol Impurity F
  • Ursodeoxycholic Acid EP Impurity F,3α-hydroxy-7-oxo-5β-cholan-24-oic acid
  • 3α-Hydroxy-7-oxo-5β-cholanic acid