URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- Product Name
- URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- CAS No.
- 347841-46-7
- Chemical Name
- URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- Synonyms
- Ursodeoxycholic-d4 Acid;2H4]-Ursodeoxycholic Acid;URSODEOXYCHOLIC-2,2,4,4-D4 ACID;Urosodeoxycholic Acid Impurity 28;Ursodeoxycholic acid-[d4] (Solution);Ursodiol-d4 (Ursodeoxycholic Acid-d4);Ursodeoxycholic Acid-2,2,4,4-d4 (Major);Ursodeoxycholic Acid-d4 MaxSpec? Standard;*Dronedarone Impurity 37 ( Tributylamine);URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY
- CBNumber
- CB3755802
- Molecular Formula
- C24H40O4
- Formula Weight
- 392.58
- MOL File
- 347841-46-7.mol
URSODEOXYCHOLIC-2,2,4,4-D4 ACID Property
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 21892
- Product name
- Ursodeoxycholic Acid-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 500μg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 21892
- Product name
- Ursodeoxycholic Acid-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 1mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 21892
- Product name
- Ursodeoxycholic Acid-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 5mg
- Price
- $575
- Updated
- 2024/03/01
- Product number
- D2127
- Product name
- Ursodeoxycholic-2,2,4,4-d4acid
- Packaging
- 5mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- 13102
- Product name
- UrsodeoxycholicAcid-[d4]
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $288
- Updated
- 2021/12/16
URSODEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties,Usage,Production
Description
Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
Uses
Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.