HEXANOIC ANHYDRIDE Chemical Properties

Melting point:

-40 °C

Boiling point:

246-248 °C (lit.)

Density 

0.928 g/mL at 20 °C (lit.)

vapor pressure 

2.9Pa at 25℃

refractive index 

n20/D 1.428(lit.)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

ethanol: soluble1g/10 mL, clear, colorless

form 

Liquid

color 

Clear colorless to light yellow

explosive limit

0.7%(V)

Water Solubility 

Hydrolyzes in water.

Sensitive 

Moisture Sensitive

BRN 

1776561

LogP

4.45 at 25℃

CAS DataBase Reference

2051-49-2(CAS DataBase Reference)

EPA Substance Registry System

Hexanoic acid, anhydride (2051-49-2)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

HEXANOIC ANHYDRIDE Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

Hexanoic anhydride has been used in:

• green synthesis of esters of acyclovir (acyclovir prodrugs)
• preparation of hexanoyl-modified chitosan nanoparticles and chitosan-based polymeric surfactants via N-acylation of chitosans

Uses

Hexanoic anhydride was used in:

• green synthesis of esters of acyclovir (acyclovir prodrugs)
• preparation of hexanoyl-modified chitosan nanoparticles
• preparation of chitosan-based polymeric surfactants via N-acylation of chitosans

Uses

Hexanoic Anhydride, is used as a reactant in the total synthesis of acremomannolipin A via steroselective β-mannosylation of 4,6,-O-benzylidene-protected mannosyl sulfoxide with a D-mannitol derivative.

Preparation

To an ice-cooled flask containing 116 gm (1.0 mole) of n-caproic acid is added 21.0-23.10 gm (0.5-0.55 mole) of ketene at a rate of 0.45 mole/hr. The reaction mixture is fractionally distilled at atmospheric pressure to afford a forecut of acetone, acetic acid, and acetic anhydride. The oil bath is raised to 220°C over a 1-hr period, kept there for 3 hr to ensure complete removal of acetic acid, and then cooled. The distillation is continued under reduced pressure to afford 86-95 gm (80-87%), b.p. 109- 112°C (3 mm Hg) and b.p. 118-121°C (6 mm Hg).

Flammability and Explosibility

Not classified

HEXANOIC ANHYDRIDE(2051-49-2)Related Product Information

• OCTANOPHENONE
• METHYL PROPYL SULFIDE
• 1-Mercaptooctane
• BEHENIC ANHYDRIDE
• N-CAPRYLIC ANHYDRIDE
• 2-ETHYLHEXANOIC ANHYDRIDE
• OLEIC ANHYDRIDE
• NONANOIC ANHYDRIDE
• LAURIC ANHYDRIDE
• HEPTANOIC ANHYDRIDE
• STEARIC ANHYDRIDE
• RUBRATOXIN B
• HEXANOIC ANHYDRIDE
• MYRISTIC ANHYDRIDE
• DECANOIC ANHYDRIDE
• Palmitic anhydride
• PERFLUOROOCTANOIC ANHYDRIDE
• LINOLEIC ANHYDRIDE