(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHANOL Chemical Properties

Boiling point:

117-118°C 0,8mm

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.37±0.10(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

29339900

(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHANOL Usage And Synthesis

Chemical Properties

Light yellow solid

Synthesis

Step 1: Preparation of (2,5-dimethyl-2H-pyrazol-3-yl) methanol (14): to a solution of compound 13 (4.5 g, 24.7 mmol) in THF (60 mL) was added lithium aluminum hydride (LiAlH4) (1.22 g, 32.1 mmol) in batches at 0°C under nitrogen atmosphere. The reaction mixture was stirred at the same temperature for 2-3 h. The excess LiAlH4 was subsequently quenched by addition of saturated sodium sulfate solution.The reaction mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to afford the target product (2,5-dimethyl-2H-pyrazol-3-yl) methanol (14) 3 g as a brown solid. Yield: 86%; 1H NMR (200 MHz, CDCl3): δ 6.0 (s, 1H), 4.57 (d, J = 5.9 Hz, 2H), 3.8 (s, 3H), 3.16 (s, 1H), 2.24 (s, 3H); Mass Spectrometry (CI method, isobutane): 127 (M+1, 100%); IR (KBr, cm-1 ): ν max 3281.

References

[1] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 98

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