EQUILENIN Chemical Properties

Melting point:

258-259°

alpha 

D16 +87° (12.8 mg made up to 1.8 ml in dioxane)

Boiling point:

349.54°C (rough estimate)

Density 

1.1305 (rough estimate)

refractive index 

1.4800 (estimate)

Flash point:

2 °C

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

pKa 9.72 (H2O t=25.0±0.02 ) (Uncertain);9.75±0.06 (Uncertain)

form 

Solid

color 

Pale Yellow to Light Beige

optical activity

+10025 (1% in dioxane)

Water Solubility 

1.52mg/L(25 ºC)

EPA Substance Registry System

Equilenin (517-09-9)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36-48-40

Safety Statements 

16-26-36-36/37

RIDADR 

UN 1648 3/PG 2

WGK Germany 

2

EQUILENIN Usage And Synthesis

Uses

Equilenin is a naturally occuring estrogenic steroidal hormone (1,2) isolated from urine of pregnant mares (3). Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Uses

Estrogenic steroidal hormone isolated from urine of pregnant mares. Occurs naturally in the d-form. Not found in human urine. Component of conjugated estrogenic hormones. Estrogen.

Definition

ChEBI: Equilenin is a 3-hydroxy steroid that is estrone which carries two double bonds at positions 6 and 8. It is found in the urine of pregnant mare's and extensively used for estrogen replacement therapy in postmenopausal women. It has a role as a mammalian metabolite and an antioxidant. It is a 3-hydroxy steroid and a 17-oxo steroid.

Purification Methods

Crystallise (+)-equilenin from EtOH (solubility is 0.63% at 18o, 2.5% at 78o), aqueous EtOH or *C6H6 (Norite) and dry it in a vacuum. It sublimes on melting and at 170-180o/0.01mm. The acetate crystallises from MeOH with m 165-167o and [ ] D +71o (c 1, CHCl3). [Bachmann et al. J Am Chem Soc 62 824 1940, Beilstein 8 III 1522, 1523, 1525, 8 IV 1420.]

EQUILENIN(517-09-9)Related Product Information

• EQUILENIN
• EQUILENIN-4,16,16-D3
• D-EQUILENIN METHYL ETHER
• D-EQUILENIN BENZYL ETHER
• D-EQUILENIN ACETATE
• EQUILENIN SODIUM SULPHATE,EQUILENIN SODIUM SULFATE,Sodium equilenin sulfate
• 4-BROMOEQUILENIN
• D-EQUILENIN ETHYL ETHER
• D-EQUILENIN BENZOATE
• 17β-Equilenin
• Equilin-d4
• equilenin benzoate
• equilenin-3,4-quinone
• Equilenin acetate
• Equilenin 3-methyl ether,Equilenin methyl ether
• 14BETA-EQUILENIN
• equilenin sulfatase
• 4-hydroxyequilenin