JAK3 INHIBITOR VI
JAK3 INHIBITOR VI Basic information
- Product Name:
- JAK3 INHIBITOR VI
- Synonyms:
-
- JAK3 INHIBITOR VI
- JI6
- CAS:
- 856436-16-3
- MF:
- C19H17N3O4S
- MW:
- 383.42098
- Mol File:
- 856436-16-3.mol
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JAK3 INHIBITOR VI Chemical Properties
- storage temp.
- +2C to +8C
- form
- Yellow solid
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JAK3 INHIBITOR VI Usage And Synthesis
General Description
A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
Biochem/physiol Actions
Cell permeable: yes