4-CHLORO-2-METHOXYBENZALDEHYDE Chemical Properties

Melting point:

70-75°C

Boiling point:

268.8±20.0 °C(Predicted)

Density 

1.244±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

WGK Germany 

3

HS Code 

2913000090

4-CHLORO-2-METHOXYBENZALDEHYDE Usage And Synthesis

Synthesis

The reaction was carried out with 2-fluoro-4-chlorobenzaldehyde (300 mg, 1.89 mmol) and sodium methanol (3784 μL, 1.89 mmol, methanol solution) with stirring at 50 °C for 3 hours. Upon completion of the reaction, the reaction mixture was concentrated to half of the original volume and subsequently purified by Biotage 25 column chromatography using 5% ethyl acetate/hexane as eluent to finally obtain 4-chloro-2-methoxybenzaldehyde (250 mg, 1.47 mmol, 77.5% yield).

References

[1] Patent: WO2009/158426, 2009, A1. Location in patent: Page/Page column 140
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5037 - 5041
[3] Angew. Chem., 2018, vol. 130, # 18, p. 5131 - 5135,5

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