Pirtobrutinib
Pirtobrutinib Basic information
- Product Name:
- Pirtobrutinib
- Synonyms:
-
- 1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-
- (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide
- Pirtobrutinib
- Pirtobrutinib (LOXO-305)
- LY 3527727
- loxo-305
- (S)-5-Amino-3-{4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-phenyl}-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-pyrazole-4-carboxylic acid amide
- LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation
- CAS:
- 2101700-15-4
- MF:
- C22H21F4N5O3
- MW:
- 479.43
- Product Categories:
-
- api
- Pirtobrutinib
- Mol File:
- 2101700-15-4.mol
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Pirtobrutinib Chemical Properties
- Boiling point:
- 619.2±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, stored under nitrogen
- solubility
- DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
- form
- A solid
- pka
- 13.32±0.46(Predicted)
- color
- White to yellow
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Pirtobrutinib Usage And Synthesis
Description
Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.
PirtobrutinibSupplier
Wuhan rheniuhui Biotechnology Co., Ltd Gold
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- 18062115889
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Chengdu Yunyidian Biological Technology Co.,Ltd Gold
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- 17621298782
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ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
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- 15000803246 18149758185
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd Gold
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- 028-83379370 13880556291
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Chunchuang (Wuhan) Technology Co., Ltd Gold
- Tel
- 15342225168
- yutianchun2007@126.com