Ethyl 3-Amino-4-methylbenzoate Chemical Properties

Melting point:

48.6-50.1℃

Boiling point:

105°C/0.2mmHg(lit.)

Density 

1.103±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

soluble in Methanol

form 

powder to crystal

pka

3.35±0.10(Predicted)

color 

White to Almost white

InChIKey

MCNBNDUVWQEKNZ-UHFFFAOYSA-N

Safety Information

HS Code 

2922498590

Ethyl 3-Amino-4-methylbenzoate Usage And Synthesis

Synthesis

Dissolve 10 g of palladium on carbon (10%) and 140 g of ammonium formate in 400 ml of methanol, and then dissolve 136 g of ethyl 3-nitro-4-methylbenzoate (2) in 400 ml of methanol. Add the methanol solution of (2) dropwise to the reaction flask at room temperature. The reaction exotherms until the methanol boils. Continue the dropwise addition. After the dropwise addition, TLC detects the completion of the reaction and filters the palladium carbon. Concentrate the methanol, add 400ml of water, and filter to obtain 156g of white solid ethyl 3-amino-4-methylbenzoate (Ethyl 3-Amino-4-methylbenzoate) as a wet product, which can be used in the next step without drying.

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