(±)-4-aminohex-5-enoic acid
(±)-4-aminohex-5-enoic acid Basic information
- Product Name:
- (±)-4-aminohex-5-enoic acid
- Synonyms:
-
- (±)-4-aminohex-5-enoic acid
- CPP 109
- 5-Hexenoic acid, 4-amino-
- SABRIL; Γ-VINYL-GABA
- rac-VigabatrinDiscontinued See V253010
- (+/-)-Vigabatrin
- Vigabatrin, racemic mixture
- Vigabatrin hydrochloride salt, racemic mixture
- CAS:
- 68506-86-5
- MF:
- C6H11NO2
- MW:
- 129.16
- EINECS:
- 270-929-6
- Mol File:
- 68506-86-5.mol
(±)-4-aminohex-5-enoic acid Chemical Properties
- Melting point:
- 209℃
- Boiling point:
- 277.7±28.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- pka
- 4.36±0.10(Predicted)
- form
- Solid
- color
- Off-White
- Water Solubility
- Soluble to 100 mM in water
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- MP7745000
- HS Code
- 2922498050
- Hazardous Substances Data
- 68506-86-5(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 3gm/kg
(±)-4-aminohex-5-enoic acid Usage And Synthesis
Uses
rac-Vigabatrin a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.
Definition
ChEBI: Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor.
Biochem/physiol Actions
Irreversible GABA transaminase inhibitor. Increases intracellular concentration of GABA in nerve endings; possesses antiepileptic activity.
in vivo
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin[1].
storage
Store at +4°C
(±)-4-aminohex-5-enoic acidSupplier
- Tel
- 029-88294447 029-88292246 029-88296135
- cjoesale@xacjoe.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 021-24206007 13764915196
- sales@balmxy.com
- Tel
- 0571-87396432
- sales@jhechem.com