sulforidazine Chemical Properties

Melting point:

121-123°

Boiling point:

589.1±50.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Refrigerator, Under Inert Atmosphere

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

9.83±0.10(Predicted)

color 

Off-White to Dark Yellow

sulforidazine Usage And Synthesis

Chemical Properties

Thick Yellow Oil

Originator

Sulforidazine,ZYF Pharm Chemical

Uses

Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).

Definition

ChEBI: Sulforidazine is a member of phenothiazines.

Manufacturing Process

A mixture of 96.5 g 2-methylsulfonylphenothiazine, 50 g 2-(2-chloroethyl)-1- methylpiperidine, 62 g diethyl carbonate and 2 g sodium methylate was heated at 135°C for 1 hour and then at 180-190°C for 2.5 hours. The product was dissolved in benzene (500 ml) and the solution was extracted with 700 ml of 15% aqueous solution tartaric acid. The extract was washed with benzene. After addition of sodium carbonate solution to the extract was obtained a precipitate which was dissolved in benzene. This solution was washed with water and concentrated. 2-Methylsulfonyl-10-(2-(1-methyl-2- piperidyl)ethyl)phenothiazin was recrystallized from acetone, melting point 121-123°C.

Therapeutic Function

Neuroleptic

sulforidazine (14759-06-9)Related Product Information

• mesoridazine
• Thioridazine-d3 Hydrochloride
• Fondaparinux Sodiun
• SULFACHLOROPYRIDAZINE
• propyrisulfuron
• Sulfamethoxypyridazine
• Metazulfuron
• 2-(2-Chloroethyl)-1-methylpiperidine hydrochloride
• Northioridazine Hydrochloride
• Thioridazine hydrochloride
• thioridazine-5-sulfoxide
• N-METHYLPIPERIDINE-2-ETHANOL
• 2-(Methylsulfonyl)-10H-phenothiazine 5-Oxide
• Thioridazine EP Impurity D
• 2-methylsulfonyl-10-[2-[1-(trideuteriomethyl)piperidin-2-yl]ethyl]phenothiazine
• 2-(2-hydroxyethyl)piperidine-1-carbaldehyde
• Thioridazine-d3 5-Sulfoxide
• Thioridazine EP Impurity A