KRIBB 3
KRIBB 3 Basic information
- Product Name:
- KRIBB 3
- Synonyms:
-
- KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole)
- 4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-isoxazol-5-ylidene]-1-cyclohexa-2,4-dienone
- Phenol, 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]-
- 4-Ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]phenol
- KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole), Hsp27 inhibitor
- CAS:
- 129414-88-6
- MF:
- C19H19NO4
- MW:
- 325.36
- Mol File:
- 129414-88-6.mol
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KRIBB 3 Chemical Properties
- Melting point:
- 147-148 °C
- Boiling point:
- 467.5±45.0 °C(Predicted)
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 25 mM
- form
- A solid
- pka
- 8.51±0.48(Predicted)
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KRIBB 3 Usage And Synthesis
Uses
Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI50 of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models[1].
References
[1] Shin KD, et al., KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochem Pharmacol. 2008 Jan 15;75(2):383-94. DOI:10.1016/j.bcp.2007.08.027
KRIBB 3Supplier
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing1@energy-chemical.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com
Shanghai Yifei Biotechnology Co. , Ltd.
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com