Dianhydrogalactitol
Dianhydrogalactitol Basic information
- Product Name:
- Dianhydrogalactitol
- Synonyms:
-
- Dianhydrogalactitol
- Dianhydrodulcitolum
- 1,2,5,6-DIANHYDRODULCITOL
- 1,2:5,6-Diepoxyhexane-3,4-diol
- 1,2-Di(oxiranyl)ethylene glycol
- Dulcitol diepoxide
- NSC-132313
- 1,2:5,6-Dianhydrogalactitol
- CAS:
- 23261-20-3
- MF:
- C6H10O4
- MW:
- 146.14
- Product Categories:
-
- APIS
- Mol File:
- 23261-20-3.mol
Dianhydrogalactitol Chemical Properties
- Melting point:
- 96.5-98.5 °C
- Boiling point:
- 185.74°C (rough estimate)
- Density
- 1.567
- refractive index
- 1.4310 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 13.53±0.20(Predicted)
Dianhydrogalactitol Usage And Synthesis
Uses
Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.
Biological Activity
val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.
in vitro
VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.
in vivo
VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.
target
DNA
References
http://www. delmarpharma.com/product_development_programs/val083/
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