Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) Basic information
- Product Name:
- Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms:
-
- Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
- (S)-tert-butyl 1-aminopropan-2-ylcarbamate
- tert-butyl N-[(2S)-1-aMinopropan-2-yl]carbaMate
- N-((S)-2-Amino-1-methylethyl)carbamic acid tert-butyl ester
- tert-Butyl ((S)-1-aminopropan-2-yl)carbamate
- ((S)-2-Amino-1-methyl-ethyl)-carbamic acid tert-butyl ester
- (S)-N2-Boc-1,2-propanediamine
- (S)-2-N-Boc-propane-1,2-diaMine
- CAS:
- 146552-71-8
- MF:
- C8H18N2O2
- MW:
- 174.24
- Product Categories:
-
- N-BOC
- Mol File:
- 146552-71-8.mol
Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties
- Boiling point:
- 264℃
- Density
- 0.984
- Flash point:
- 113℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.19±0.46(Predicted)
- Appearance
- Yellow to brown Solid
Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis
Synthesis
146610-69-7
146552-71-8
General procedure for the synthesis of tert-butyl (S)-(1-aminopropan-2-yl)carbamate from the compound (CAS: 146610-69-7): Pd/C (10%, 2 g) was added to a solution of tert-butyl (S)-1-azidopropan-2-ylcarbamate (75.0 g, 0.375 mol) in methanol (1 L). The suspension was stirred at room temperature under hydrogen atmosphere for 4 hours. After completion of the reaction, the reaction mixture was filtered and the solid was washed with methanol (100 mL). The combined filtrates were concentrated under vacuum to afford tert-butyl (S)-1-aminopropan-2-ylcarbamate (65.1 g, quantitative yield), which was used directly in the next step without further purification.1H NMR (300 MHz, CDCl3) δ ppm: 4.64 (br s, 1H), 3.64 (m, 1H), 2.75 (dd, J = 13.2, 5.1 Hz, 1H), 2.63 (dd, J = 13.2, 6.6 Hz, 1H), 1.45 (s, 9H), 1.31 (br s, 2H), 1.12 (d, J = 6.6 Hz, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 24, p. 5743 - 5747
[2] Journal of Chemical Research, Miniprint, 1992, # 12, p. 3117 - 3132
[3] Patent: US2004/208828, 2004, A1. Location in patent: Page 13
[4] Organic Letters, 2011, vol. 13, # 13, p. 3486 - 3489
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 17, p. 2780 - 2786
Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)Supplier
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Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)(146552-71-8)Related Product Information
- S-2-N-BOC-propane-1,2-diamine-HCl
- (S)-[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
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- (R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester
- benzyl 2-aMinopropylcarbaMate
- (R)-benzyl 2-aMinopropylcarbaMate
- 1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester, (3S,5S)-
- Carbamic acid, (2-amino-1-methylethyl)-, 1,1-dimethylethyl ester (9CI)
- (R)-tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-
- 2-N-BOC-propane-1,2-diamine-HCl
- [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
- (R)-[1-(4-Bromophenyl)ethyl]carbamic acid tert-butyl ester
- 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- (3R,5R)-1-Boc-3,5-diMethylpiperazine
- S-1-N-CBZ-propane-1,2-diamine-HCl
- S-2-N-BOC-propane-1,2-diamine hydrochloride