Tirilazadmesylate Chemical Properties

Boiling point:

812.9±75.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

pka

12.04±0.50(Predicted)

form 

Solid

color 

Off-white to light yellow

Tirilazadmesylate Usage And Synthesis

Uses

Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

Definition

ChEBI: Tirilazad is a corticosteroid hormone.

References

[1] Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087. DOI:10.1002/14651858.CD002087
[2] Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778. DOI:10.1002/14651858.CD006778.pub2
[3] Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65. DOI:10.1161/01.str.31.9.2257

Tirilazadmesylate(110101-66-1)Related Product Information

• DESMETHYL TIRILAZAD,METHYLATED TIRILAZAD
• 1-N-NONYLPIPERAZINE
• TIRILAZAD MESYLATE
• 4-AMINO-6-(4-METHYL-1-PIPERAZINYL)PYRIMIDINE
• 2,4-BIS(DIMETHYLAMINO)-PYRIMIDINE
• 1-(1-HEPTYL)-PIPERAZINE
• 1-OCTYLPIPERAZINE
• 1-(4-methylpiperazin-1-yl)acetone
• 1-DECYLPIPERAZINE
• 4-(PIPERAZIN-1-YL)-2,6-DI-(PYRROLIDIN-1-YL)-PYRIMIDINE
• 2,4,6-Triaminopyrimidine
• 2-Pyrimidinamine,4-(1-piperazinyl)-(9CI)
• Tirilazadmesylate