U-74389G Chemical Properties

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

ethanol: soluble20 mg/mL, clear, light yellow

form 

White solid.

color 

White

Sensitive 

Hygroscopic

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

U-74389G Usage And Synthesis

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

Uses

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

References

1) Braughler et al. (1987) Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation; J. Biol. Chem., 262 10438 2) Campo et al. (1996) Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation; J. Pharmacol. Exp. Ther., 277 333 3) Perna et al. (1996) Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G; Pharmacol. Res., 34 25

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