Basic information Safety Supplier Related

U-74389G

Basic information Safety Supplier Related

U-74389G Basic information

Product Name:
U-74389G
Synonyms:
  • U-74389G
  • (Z)-2-BUTENEDIONATE
  • 21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE
  • 21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIONATE
  • 21-(4-(2,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIOATE
  • 21-[4-(4,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL]-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE MALEATE
  • METHYLATED TIRILAZAD
  • DESMETHYL TIRILAZAD
CAS:
153190-29-5
MF:
C41H54N6O6
MW:
726.9
Mol File:
153190-29-5.mol
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U-74389G Chemical Properties

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
ethanol: soluble20 mg/mL, clear, light yellow
form 
White solid.
color 
White
Sensitive 
Hygroscopic
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety Information

WGK Germany 
3

MSDS

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U-74389G Usage And Synthesis

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

Uses

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

in vivo

U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change[2].
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3].

Animal Model:Rat model of trinitrobenzenesulfonic acid-induced colitis[2]
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; once daily; 6 d
Result:Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
Animal Model:Male Sprague–Dawley rats injected with Lipopolysaccharide[3]
Dosage:15 or 30 mg/kg
Administration:Intravenous injection; 15 or 30 mg/kg
Result:Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).

References

[1] J. BRAUGHLER. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.[J]. The Journal of Biological Chemistry, 1987, 27 1: 10438-10440. DOI:10.1016/s0021-9258(18)60979-2
[2] G M CAMPO. Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 333-340.
[3] A.M. PERNA . PROTECTION OF RAT HEART FROM ISCHAEMIA-REPERFUSION INJURY BY THE 21-AMINOSTEROID U-74389G[J]. Pharmacological research, 1996, 34 1: Pages 25-31. DOI:10.1006/phrs.1996.0059

U-74389GSupplier

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
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U-74389G(153190-29-5)Related Product Information