Foropafant
Foropafant Basic information
- Product Name:
- Foropafant
- Synonyms:
-
- Foropafant
- 4-(2,4,6-Triisopropylphenyl)-N-[2-(dimethylamino)ethyl]-N-(3-pyridylmethyl)thiazol-2-amine
- SR 27417
- N-(2-Dimethylaminoethyl)-N-(3-pyridylmethyl)-4-(2,4,6-triisopropylphenyl)thiazol-2-amine
- N1,N1-dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-diamine
- N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-di
- Faropafant
- N,N-Dimethyl-N′-(3-pyridinylmethyl)-N′-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine
- CAS:
- 136468-36-5
- MF:
- C28H40N4S
- MW:
- 464.71
- Mol File:
- 136468-36-5.mol
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Foropafant Chemical Properties
- Boiling point:
- 571.6±60.0 °C(Predicted)
- Density
- 1.065±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble5mg/mL (clear solution, warmed)
- pka
- 8.75±0.28(Predicted)
- form
- powder
- color
- white to beige
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Foropafant Usage And Synthesis
Uses
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].
Biochem/physiol Actions
SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist.
References
[1] Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. DOI:10.1016/j.ejmech.2019.01.043
ForopafantSupplier
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