Melagatran Chemical Properties

Melting point:

198-200°C

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.12±0.10(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

Melagatran Usage And Synthesis

Chemical Properties

White Solid

Uses

Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.

Definition

ChEBI: Melagatran is a member of the class of azetidines that is (2S)-azetidine 2-carboxylic acid in which the carboxylic acid has been converted to the amide corresponding to formal condensation with 4-(aminomethyl)benzenecarboximidamide and in which the hydrogen attached to the azetidine nitrogen is replaced by a (2R)-2-cyclohexyl-2-[(carboxymethyl)amino]acetyl group. It has a role as an anticoagulant, an EC 3.4.21.5 (thrombin) inhibitor and a serine protease inhibitor. It is a carboxamidine, a dicarboxylic acid monoamide, a non-proteinogenic alpha-amino acid, a secondary amino compound and a member of azetidines.

Melagatran(159776-70-2)Related Product Information

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