Fexinidazole Chemical Properties

Boiling point:

501 °C

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: 20 mg/mL; DMF:PBS (pH 7.2) (1:8): 0.11 mg/mL; DMSO: 10 mg/mL; Ethanol: 0.2 mg/mL

form 

A crystalline solid

pka

1.82±0.25(Predicted)

color 

Light yellow to yellow

Fexinidazole Usage And Synthesis

Uses

Fexinidazole is a medication used in the treatment of African trypanosomiasis caused by trypanosoma brucei gambiense. An antitrypanosomal agent. It also functions as a medication used against the main species that cause visceral and cutaneous new World leishmaniasis.

Biological Activity

Anti Trypanosoma, Leishmania agent.', 'Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites th at are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.

Fexinidazole(59729-37-2)Related Product Information

• Tinidazole
• Metronidazole gel
• (1-Methyl-1H-imidazol-2-yl)methanol
• 1-Methyl-5-nitro-1H-imidazole-2-methanol
• Fexinidazole