ANTI-CYTOCHROME C
ANTI-CYTOCHROME C Basic information
- Product Name:
- ANTI-CYTOCHROME C
- Synonyms:
-
- ANTI-APAF-2 (AB-1), RABBIT
- ANTI-APAF-2 (AB-1) SHEEP PAB
- ANTI-APAF-2 (AB-2), MAMMALIAN
- ANTI-HUMAN CYTOCHROME C
- ANTI-HUMAN/MOUSE/RAT CYTOCHROME C
- ANTI-CYTOCHROME C(H-104)
- ANTI-CYTOCHROME C MAB
- ANTI-CYTOCHROME C MOUSE MAB
- MW:
- 0
- Mol File:
- Mol File
ANTI-CYTOCHROME C Chemical Properties
- storage temp.
- -20°C
- form
- buffered aqueous solution
- biological source
- sheep
MSDS
- Language:English Provider:SigmaAldrich
ANTI-CYTOCHROME C Usage And Synthesis
Uses
Anti-Cytochrome c antibody produced in sheep has been used in:
- immunocytochemistry
- immunostaining
- immunoblotting
- immunohistochemistry
General Description
Anti-Cytochrome c produced in sheep using purified rabbit cytochrome c conjugated to keyhole limpet hemocyanin (KLH).
Biochem/physiol Actions
Cytochrome c controls cellular electron transport and energy metabolism. It is involved in the transfer of electrons between complex III and complex IV in the mitochondrial electron transport chain. It is involved in apoptosis and activates the death protease caspase-3 (CCP32). The presence of Bcl-2 on the organelles inhibits the release of cytochrome c from mitochondria during apoptosis. Along with Apaf-1, and procaspase-9, it forms an essential component of vertebrate ”apoptosome”. Activation of caspase-9 and other capsases directs apoptosis. Serum cytochrome c is a sensitive apoptotic marker in vivo, and increased serum cytochrome c level can serve as a negative prognostic marker.