9(R)-HODE Chemical Properties

Boiling point:

416.1±33.0 °C(Predicted)

Density 

0.970±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml

pka

4.78±0.10(Predicted)

9(R)-HODE Usage And Synthesis

Uses

9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.

Definition

ChEBI: 9(R)-HODE is a 9-HODE in which the 9-hydroxy group has R-stereochemistry. It is a conjugate acid of a 9(R)-HODE(1-). It is an enantiomer of a 9(S)-HODE.

References

[1] Camacho, et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J. Biol. Chem. 270(29), 17279-17286 (1995).

9(R)-HODE(10075-11-3)Related Product Information

• CIS-10,TRANS-12-CONJUGATEDLINOLEICACID
• (+/-)9-HODE
• 9(R)-HODE