Basic information Safety Supplier Related

2'-deoxy-4'-thiocytidine

Basic information Safety Supplier Related

2'-deoxy-4'-thiocytidine Basic information

Product Name:
2'-deoxy-4'-thiocytidine
Synonyms:
  • 2'-deoxy-4'-thiocytidine
  • Cytidine, 2'-deoxy-4'-thio-
  • 4′-thio-2-deoxycytidine
  • 4’-thio-2’-deoxycytidine
  • Cytidine,2'-deoxy-4'-thio- (9CI)
CAS:
134111-30-1
MF:
C9H13N3O3S
MW:
243.28
Mol File:
134111-30-1.mol
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2'-deoxy-4'-thiocytidine Usage And Synthesis

Uses

2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant p21 increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts[1].

References

[1] Sherry X Yang, et al. TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. J Hematol Oncol. 2021, 14, 1. DOI:10.1186/s13045-021-01091-5

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